Orthobiologic injections for treating degenerative meniscus lesions: a matter of facts? Ten years of clinical experience in a systematic review

IntroductionThe treatment of degenerative meniscal lesions usually consists conservative measures such as physical therapy or knee injections. Recently, the use orthobiologics, in form platelet-rich plasma and cell-based therapies, gained huge popularity orthopedic practice.ObjectivesThe aim present systematic review is to summarize available evidence concerning orthobiologics lesions.Data sourcesA comprehensive search PubMed, Google Scholar, Cochrane, EMBASE was performed using various combinations following keywords: meniscus AND (platelet OR BMAC bone marrow adipose stromal vascular fraction placental cord jelly).Study eligibility criteria, participants, interventionsArticles were screened according inclusion criteria: (1) clinical reports randomized trials that included injections treat lesions; (2) written English language; (3) published from 2012 2022.ResultsNine studies finally review: 8 for 1 micro-fragmented tissue. All reported functional improvements treated with orthobiologics.LimitationsIncluded highlight considerable heterogeneity methodological approaches. Differences product choice, outcome measures, follow-up preclude ability generate definitive suggestions application everyday practice.Conclusions implications key findingsThe literature suggests may offer a new effective therapeutic strategy lesions.